Glypican-3 is a protein which is encoded by the GPC3 gene in humans The protein core of GPC3 consists of two subunits where the N-terminal subunit has a size of 40 kDa and the C-terminal subunit is 30 kDa Glypican 3 is a potential therapeutic target for treating liver cancer and other cancers Several therapeutic anti-GPC3 antibodies have been developed